Here's all the team news and previews ahead of Saturday night's Barclays Premier League matches.
Bolton vs Chelsea
Chelsea have doubts over striker Salomon Kalou and defender Branislav Ivanovic ahead of their trip to Bolton.
Both will undergo late fitness tests after collecting minor knocks in the Carling Cup win over Wanderers in midweek.
But Ashley Cole (ankle), Jose Bosingwa (knee), Yury Zhirkov (knee), John Mikel Obi (knee) and Hilario (concussion) are all out.
However, Chelsea welcome back John Terry, Ricardo Carvalho, Nicolas Anelka, Michael Essien and Frank Lampard. They were all rested in midweek.
Bolton boss Gary Megson has an almost fully fit squad to pick from.
Striker Johan Elmander made his return to first-team action after a hamstring injury when he came off the bench against Chelsea in the Carling Cup tie between the two teams on Wednesday night.
Only long-term absentees Joey O'Brien and Sean Davis, who both have knee problems, remain on the sidelines.
Teams:
Bolton (from): Jaaskelainen, Al Habsi, Ricketts, Steinsson, Knight, Cahill, A O'Brien, Samuel, Robinson, M Davies, Basham, Muamba, Cohen, McCann, Gardner, Taylor, K Davies, Klasnic, Lee, Elmander.
Chelsea (from): TBA
Man United vs Blackburn
Manchester United manager Sir Alex Ferguson is facing a defensive headache ahead of the Premier League match against Blackburn at Old Trafford on Saturday.
Nemanja Vidic and Rio Ferdinand are both doubtful with calf problems and Gary Neville is suspended.
Ryan Giggs also has a knock and Danny Welbeck, who scored in the Carling Cup victory against Barnsley in midweek, is sidelined with a knee injury.
Darren Fletcher and Ji-Sung Park remain absent with groin and knee injuries respectively.
Jason Roberts is the latest Blackburn player to come down with suspected swine flu.
The striker did not report to training on Friday morning and is almost certain to miss out.
One player also thought to have suffered with the virus is David Dunn, but the midfielder looked to be in good health when he came off the bench against Peterborough in the Carling Cup on Tuesday night, and is set to play again.
Another is Chris Samba, who is back in training but unlikely to feature as he is still feeling weak.
Pascal Chimbonda returns having recovered from his calf injury and Vince Grella is back in training after his thigh problem, but is unlikely to appear for the first team until next week.
Teams:
Manchester United (from): Van der Sar, Kuszczak, Foster, O'Shea, Vidic, Ferdinand, Brown, J Evans, Evra, Anderson, Rafael, Carrick, Scholes, Valencia, Giggs, Rooney, Barbatov, Nani, Owen, Macheda, Obertan, Fabio, Tosic.
Blackburn (from): Robinson, Chimbonda, Salgado, Givet, Nelsen, Diouf, Andrews, Pedersen, Dunn, Brown, Jacobsen, Nzonzi, Emerton, Hoilett, Kalinic, McCarthy, Olsson, Jones, Di Santo.
Tottenham vs Arsenal
Manuel Almunia could be set for a recall to Arsenal's starting XI for Saturday's derby with Tottenham.
Arsene Wenger is likely to make several changes from the side which beat Liverpool in the Carling Cup in midweek but Lukas Fabianski (thigh), Tomas Rosicky and Theo Walcott (both knee) miss out.
Samir Nasri made his first appearance of the season against Liverpool after recovering from a broken leg and is likely to be on the bench on Saturday.
Teams:
Arsenal (from): Mannone, Clichy, Gallas, Vermaelen, Sagna, Eboue, Song, Fabregas, Diaby, Arshavin, van Persie, Almunia, Eduardo, Vela, Gibbs, Silvestre, Wilshere, Ramsey, Bendtner.
Tottenham (from): TBA
Fulham vs Liverpool
Steven Gerrard will miss his third successive Liverpool match on Saturday with the groin injury he picked up playing for England in Ukraine earlier this month.
Liverpool will also be without England full-back Glen Johnson (calf) for the game against Fulham at Craven Cottage.
Italian midfielder Alberto Aquilani, who made his first-team debut at Arsenal in the Carling Cup on Wednesday, has picked up a virus and will not be in the squad while Rafael Benitez will give a late test to Fernando Torres (groin) but expects him to be available.
Teams:
Fulham (from): TBA
Liverpool (from): Reina, Aurelio, Carragher, Agger, Skrtel, Kyrgiakos, Insua, Babel, Lucas, Mascherano, Benayoun, Kuyt, Torres, Voronin, Ngog, Plessis, Spearing, Dossena, Cavalieri, Degen.
Everton vs Aston Villa
Aston Villa goalkeeper Brad Friedel could make his 200th successive Premier League performance against Everton at Goodison Park on Saturday.
Friedel is likely to replace Brad Guzan even though his fellow American made three penalty shoot-out saves in the midweek Carling Cup win over Sunderland.
Defender Stephen Warnock is battling to overcome an ankle injury suffered against the Black Cats and Nicky Shorey could deputise if he is ruled out.
Striker Emile Heskey and midfielder Nigel Reo-Coker picked up knocks but Villa manager Martin O'Neill is hopeful of having them available.
John Carew and Steve Sidwell, who made way for the duo at the Stadium of Light, will be in contention for a recall to the starting line-up.
Everton could be without 10 senior players.
Defender Leighton Baines is poised to return from a calf injury, while striker Louis Saha, who has a similar problem, will be given time to prove his fitness.
Ayegbeni Yakubu is in contention for a place in the starting XI after overcoming his heel problem to play against Tottenham on Tuesday, while Joseph Yobo, who did not feature, could return after suffering concussion.
Teams:
Everton (from): Howard, Hibbert, Heitinga, Distin, Neill, Coleman, Gosling, Rodwell, Cahill, Jo, Saha, Fellaini, Nash, Duffy, Agard, Baxter, Wallace, Akpan, Yakubu, Baines, Yobo.
Aston Villa (from): Friedel, Guzan, Cuellar, Beye, Luke Young, Collins, Dunne, Warnock, Shorey, Milner, Petrov, Sidwell, Reo-Coker, Delph, Gardner, Ashley Young, Agbonlahor, Carew, Heskey, Delfouneso, Clark.
Sunderland vs West Ham
Sunderland striker Darren Bent is facing a race to be fit for Saturday's Premier League visit of West Ham, as he battles to overcome a knee problem.
The forward missed Tuesday's Carling Cup penalty shoot-out defeat by Aston Villa but is rated as better than 50-50 for the Hammers clash, after returning to training on Thursday
Fellow striker Fraizer Campbell is a doubt after suffering a knock against Villa, while Phil Bardsley (shoulder) and George McCartney (hip) are also touch-and-go.
Midfielder Bolo Zenden and centre-back John Mensah are ruled out. Lee Cattermole is a long-term absentee with knee ligament damage.
West Ham will be without Scott Parker.
The midfielder was sent off towards the end of last Sunday's 2-2 draw with Arsenal and serves a one-match ban, so Czech midfielder Radoslav Kovac comes in.
Kieron Dyer has suffered another setback and faces three weeks out with a hamstring problem picked up in training. Italian striker Alessandro Diamanti is pushing to start following his game-turning performance as a substitute against the Gunners.
Teams:
Sunderland (from): Gordon, Fulop, Bardsley, Da Silva, Nosworthy, Ferdinand, Turner, Richardson, McCartney, Reid, Malbranque, Cana, Henderson, Campbell, Jones, Bent, Healy, Murphy.
West Ham (from): Green, Ilunga, Tomkins, Upson, Gabbidon, Noble, Faubert, Behrami, Kovac, Collison, Cole, Diamanti, Kurucz, Spector, Da Costa, Stanislas, Jimenez, Franco, Hines.
Stoke vs Wolves
Wolves welcome back striker Stefan Maierhofer for Saturday's trip to Stoke in the Premier League after the Austrian served a one-match ban.
However manager Mick McCarthy is poised to name an unchanged starting line-up, with Maierhofer on the bench as Kevin Doyle and Sylvan Ebanks-Blake continue in attack.
On-loan Chelsea central defender Michael Mancienne is available again after missing the last two games through illness.
Stoke boss Tony Pulis is expected to recall goalkeeper Thomas Sorensen to his starting line-up following the Dane's late withdrawal at Tottenham last weekend with flu.
Steve Simonsen stepped in and performed heroics to secure a 1-0 win at White Hart Lane, and was again in the side that lost 4-0 at Portsmouth in the Carling Cup on Tuesday.
Pulis also has to decide whether to bring Mamady Sidibe into the reckoning after the striker's return to action at Fratton Park following a knee injury.
Tuncay also performed well at Portsmouth and could force his way into a side still missing the suspended Robert Huth.
Teams:
Stoke (from): Sorensen, Wilkinson, Shawcross, Faye, Collins, Delap, Whelan, Whitehead, Diao, Etherington, Beattie, Tuncay, Fuller, Higginbotham, Cort, Lawrence, Kitson, Pugh, Simonsen, Sidibe.
Wolves (from): Hennessey, Hahnemann, Zubar, Stearman, Berra, Mancienne, Craddock, Elokobi, Hill, Kightly, Halford, Henry, Milijas, Surman, Castillo, Edwards, Jarvis, Ebanks-Blake, Iwelumo, Keogh, Maierhofer, Doyle.
Portsmouth vs Wigan
Wigan will be without Maynor Figueroa in their Premier League clash at Portsmouth on Saturday as he recovers from a knee injury.
The Honduran full-back is expected to be sidelined for up to seven weeks after suffering the setback in the victory against Burnley.
Paul Scharner is doubtful with a hamstring injury while goalkeeper Chris Kirkland remains troubled by a dislocated finger.
Portsmouth welcome back Kevin-Prince Boateng, Jamie O'Hara, Mike Williamson and Tommy Smith.
The quartet were cup-tied for Tuesday's Carling Cup win over Stoke.
Papa Bouba Diop (hamstring) and Hermann Hreidarsson (foot tendon) are still recovering and will not feature against the Latics.
Teams:
Portsmouth (from): James, Kaboul, Mokoena, Mullins, Kanu, Basinas, Belhadj, Vanden Borre, Piquionne, Ben-Haim, Yebda, Dindane, Finnan, Webber, Brown, Wilson, Ashdown, O'Hara, Boateng, Williamson, Smith.
Wigan (from): Kirkland, Bramble, Scharner, Gomez, Melchiot, Boyce, N'Zogbia, Diame, Thomas, Scotland, Rodallega, Koumas, Sinclair, Pollitt, Cho, Kapo, Kingson, McCarthy.
Burnley vs Hull
Troubled Hull will be without goalkeeper Boaz Myhill for Saturday's vital trip to Burnley.
The Wales international injured his medial knee ligaments in the closing stages of last weekend's goalless draw with fellow strugglers Portsmouth and will sit out the clash, though under-pressure manager Phil Brown is hopeful he will not prove a long-term absentee.
Star midfielder Jimmy Bullard did not train with his team-mates on Thursday due to a shin injury and a decision is still to be made on his participation at Turf Moor.
Burnley boss Owen Coyle will give goalkeeper Brian Jensen "every chance" to recover from the injury he sustained in last weekend's home defeat to Wigan.
X-rays revealed the Burnley stopper, who has yet to resume full training, had suffered only slight ligament damage to his ankle so Diego Penny is on stand-by.
Stephen Jordan suffered a thigh strain in the same game but he is expected to recover in time.
The Clarets are still without long-term absentees Martin Paterson, Chris McCann (both knee) and Jay Rodriguez (ankle).
Teams:
Burnley (from): Jensen, Caldwell, Mears, Eckersley, Duff, Carlisle, Bikey, Jordan, Alexander, Fletcher, Elliott, Blake, Thompson, Eagles, Penny, Kalvanes, Gudjonsson, Edgar, Easton, Nugent, Guerrero.
Hull (from): Warner, Duke, McShane, Kilbane, Sonko, Dawson, Barmby, Marney, Zayatte, Geovanni, Hunt, Vennegoor of Hesselink, Ghilas, Mendy, Altidore, Bullard, Gardner, Mouyokolo, Olofinjana, Cousin, Halmosi, Boateng, Fagan, Garcia, Cooper, Atkinson, Featherstone.
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